CBT Best For Anxiety, Depression, To Boost Immune System, Reduce Inflammation

Written by Jim Folk
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Written by Jim Folk
Written by Jim Folk
Last updated June 23, 2021
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It’s well established that Cognitive Behavioral Therapy (CBT) and its many forms is the most effective psychotherapy treatment for anxiety disorder and depression (as well as many other behavioral disorders).

Recent research has also found CBT boosts the immune system and the most effective treatment for inflammation.

Inflammation problems often co-occur with behavioral disorders due to the frequent activation of the stress response and how the stress response activates and regulates inflammatory response.

While infrequent stress response activation gives the body a boost during stressful times, frequent activation can cause issues with anxiety disorder symptoms, as well as issues with chronic inflammation.

One of the benefits of addressing behavioral problems (such as anxiety disorder and depression) with CBT is that it can boost the immune system and address problems with inflammation, as well.

Anxiety disorder and depression are linked with inflammation problems.

You can read about this research from the press release below:

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Cognitive behavior therapy tops other psychotherapies in reducing inflammation

UNIVERSITY OF CALIFORNIA – LOS ANGELES HEALTH SCIENCES

A review of 56 randomized clinical trials finds that psychological and behavioral therapies may be effective non-drug treatments for reducing disease-causing inflammation in the body.

The results of the analysis, published in JAMA Psychiatry, found that cognitive behavior therapy, or CBT, was superior to other psychotherapies at boosting the immune system.

The senior author of the new study is Dr. George Slavich, director of the UCLA Laboratory for Stress Assessment and Research. Along with two of his colleagues at UC Davis and San Diego State University, the team looked at whether interventions typically used for treating mental health problems, such as anxiety and depression, might also boost biological processes involved in physical health. They further analyzed the duration and types of psychotherapy received, including group versus non-group therapy. Finally, they examined how the treatments affected different markers of inflammation and other immune system processes in the body.

“People automatically go to medication first to reduce chronic inflammation, but medications can be expensive and sometimes have adverse side effects,” Slavich said. “In this review, we wanted to know whether psychotherapies can also affect the immune system and, if so, which ones have the most beneficial effects over the long term.”

The researchers analyzed randomized clinical trials that investigated the effects of several different types of interventions, including CBT, CBT plus medication, grief and bereavement support, a combination of two or more psychotherapies, and psychoeducation, among others.

“This seems to be a case of mind over matter,” Slavich said. “Psychotherapies like CBT can change how we think about ourselves and the world, and changing these perceptions can in turn affect our biology. The results of this study take this idea one step further and suggest that psychotherapy may be an effective and relatively affordable strategy for reducing individuals’ risk for chronic diseases that involve inflammation.”

Through their analyses, the researchers sought to better understand how the body reacts to non-drug treatments for chronic inflammation, which increases the risk of developing several deadly diseases and can lead to premature death.

They looked at several different immune outcomes. Of those outcomes, pro-inflammatory cytokines were most strongly affected by psychotherapy in general and CBT in particular. Pro-inflammatory cytokines are notable because they help the immune system heal physical wounds and battle infections. If these proteins remain persistently elevated, though, they can lead to chronic inflammation, which increases the risk of physical illnesses, such as heart disease, cancer and Alzheimer’s disease, as well as mental health problems, including anxiety disorders, depression, PTSD, schizophrenia, self-harm and suicide.

“There are many people who would prefer to use non-drug interventions for improving their immune system function,” Slavich said. “In some cases, they can’t take certain medications because of medical reasons, and in other instances the medications they need are too expensive. And then there are people who simply prefer a more holistic approach to improving their health.”

Slavich said that these findings provide strong evidence that psychotherapy may be helpful in this regard.

“Out of all of the interventions we examined, CBT was the most effective for reducing inflammation, followed by multiple or combined interventions,” Slavich said. “Moreover, we found that the benefits of CBT on the immune system last for at least six months following treatment. Therefore, if you’re looking for a well-tested, non-drug intervention for improving immune-related health, CBT is probably your best choice.”


Disclaimer: anxietycentre.com is not responsible for the accuracy of news releases posted at anxietycentre.com by contributing institutions or for the use of any information throughout anxietycentre.com’s system.


The combination of good self-help information and working with an experienced anxiety disorder therapist, coach, or counselor is the most effective way to address anxiety and its many symptoms. Until the core causes of anxiety are addressed – which we call the underlying factors of anxiety – a struggle with anxiety unwellness can return again and again. Dealing with the underlying factors of anxiety is the best way to address problematic anxiety.

Additional Resources

anxietycentre.com: Information, support, and coaching/counseling/therapy for problematic anxiety and its sensations and symptoms, including CBT Best For Anxiety, Depression, To Boost Immune System, Reduce Inflammation.