“All of us at anxietycentre.com have experienced debilitating anxiety. But we’ve also overcome it and returned to normal and lasting health. Because we know the hardship anxiety unwellness can cause, we are committed to helping others, with over 30 years of service.” - Jim Folk, President, anxietycentre.com

Placebo Effect A Major Factor in Antidepressant Response

Placebo: a substance that has no therapeutic effect

Research by University of Michigan, in Ann Arbor, headed by Marta Pecina, MD, PhD, found that the placebo response is behind much of a patient’s response to drug treatment when it comes to depressive disorder.

"Placebo response rates in depression are as high as 50%, which is pretty close to the response rates we see with antidepressant therapy, so it's important to understand placebo responses because they account for an important proportion of the actual response to antidepressant treatment," said Dr. Pecina.

Commenting on the study in a statement, senior researcher Jon-Kar Zubieta, MD, PhD, now chair, Department of Psychiatry, University of Utah, in Salt Lake City, noted that the placebo effect in this study came from participants not only believing that they were receiving a "real" drug but also from simply being in a treatment environment.

"These results suggest that some people are more responsive to the intention to treat their depression and that they may do better if psychotherapies or cognitive therapies that enhance the clinician-patient relationship are incorporated into their care." he said.

The study was published online September 30 in JAMA Psychiatry.


Disclaimer: anxietycentre.com is not responsible for the accuracy of news releases posted at anxietycentre.com by contributing institutions or for the use of any information throughout anxietycentre.com's system.


The combination of good self-help information and working with an experienced anxiety disorder coach, counselor, or therapist is the most effective way to address anxiety disorder and its many symptoms. Until the core causes of anxiety are addressed - the underlying factors that motivate apprehensive behavior - a struggle with anxiety disorder can return again and again. Identifying and successfully addressing anxiety's underlying factors is the best way to overcome problematic anxiety.


For more information about our Anxiety Counseling option; our Available Anxiety Therapists; to Book An Appointment with one of our anxiety therapists; common Anxiety Signs and Symptoms; common Anxiety Attack Symptoms; the symptoms of panic attack disorder; anxiety Recovery Support area; information about Anxiety; and our Anxiety 101 section; or click on the appropriate link or graphic below:

Anxiety Counseling
Learn More
Available Therapists
Learn More
Book An Appointment
Learn More
Anxiety Symptoms
Learn More
Anxiety Attack Symptoms
Learn More
Panic Attack Symptoms
Learn More
Recovery Support
Learn More
Anxiety
Learn More
Anxiety 101
Learn More

Return to our anxiety research page.

Authors: Jim Folk, Marilyn Folk, BScN. Last updated September 3, 2018.

anxietycentre.com: Information, support, and coaching/counseling/therapy for problematic anxiety and its sensations and symptoms, including the latest in anxiety research: Placebo Effect A Major Factor in Antidepressant Response.