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CBT Could Also Protect Cells Against Stress And Aging

Jim Folk author
Written by: Jim Folk.
Medically reviewed by: Marilyn Folk, BScN.
Last updated: December 20, 2019


cbt protects against cellular aging image

A study by Karolinska Institutet researchers has found that CBT for patients with social anxiety disorder not only helps reduce symptoms of anxiety but could also protect against accelerated cellular aging.

This is an important discovery because people affected by mental illness are at greater risk of developing somatic conditions, such as high blood pressure, diabetes, gastrointestinal disorders, autoimmune disorders, and chronic pain.

While the reasons for this increased risk remain unclear, one factor is that shorter telomeres and accelerated cellular aging are associated with mental health disorders.

The study's press release explains:

Telomeres are short sequences of DNA that cap the ends of chromosomes and protect cells, not unlike the hard tips of shoelaces. The length of the telomeres decreases with every cell division, meaning that they grow shorter with age. The telomeres are in turn protected by the enzymes telomerase (the job of which is to rebuild them) and glutathione peroxidase (which protects the cells against oxidative stress).

The study's press release further states:

The results showed that CBT greatly reduced anxiety levels in the patients while increasing the activity in the two protective enzymes telomerase and glutathione peroxidase, in direct relation to how much the patients improved.

"In our interpretation, it means that effective psychological treatment for anxiety can protect the cells against oxidative stress and cellular ageing," says Kristoffer Månsson. "This is an exciting result that can eventually allow patients to be given effective treatment based on their biological profile. But more studies are needed before we can draw any real conclusions about causality."

The study's abstract concludes:

The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes. Thus, indices of cellular protection may be involved in the therapeutic mechanisms of psychological treatment for anxiety.

This research shows that not only can CBT (talk therapy) help resolve anxiety disorder but it can also play a role in protecting against the development of somatic conditions.

The study was published in the journal Translational Psychiatry.

You can read the press release for this study below:


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CBT for social anxiety may have a protective effect on cells

KAROLINSKA INSTITUTET

Cognitive Behavioural Therapy (CBT) for patients with social anxiety not only helps to reduce anxiety levels but also seems to protect against accelerated cellular ageing, a study involving researchers at Karolinska Institutet published in the journal Translational Psychiatry reports.

"This is the first step towards better understanding the link between cellular ageing and the treatment of psychiatric issues," says lead author Kristoffer Månsson, researcher at the Department of Clinical Neuroscience at Karolinska Institutet in Sweden.

Individuals affected by mental ill-health are at greater risk of developing somatic conditions, such as high blood pressure and diabetes, earlier in life than unaffected individuals. While the reasons for this are unclear, one possible contributory factor is that mental health disorders are associated with shorter telomeres and accelerated cellular ageing.

Telomeres are short sequences of DNA that cap the ends of chromosomes and protect cells, not unlike the hard tips of shoelaces. The length of the telomeres decreases with every cell division, meaning that they grow shorter with age. The telomeres are in turn protected by the enzymes telomerase (the job of which is to rebuild them) and glutathione peroxidase (which protects the cells against oxidative stress).

The researchers behind the present study looked at the effect that Cognitive Behavioural Therapy (CBT) has on these cell markers in patients with social anxiety disorder (social phobia). Forty-six patients received nine weeks' CBT treatment via the Internet, having first provided two blood samples with a nine-week interval. Fresh blood samples were then taken as soon as their treatment programme ended in order that the cell markers could be measured.

The results showed that CBT greatly reduced anxiety levels in the patients while increasing the activity in the two protective enzymes telomerase and glutathione peroxidase, in direct relation to how much the patients improved.

"In our interpretation, it means that effective psychological treatment for anxiety can protect the cells against oxidative stress and cellular ageing," says Kristoffer Månsson. "This is an exciting result that can eventually allow patients to be given effective treatment based on their biological profile. But more studies are needed before we can draw any real conclusions about causality."

As expected, the length of the telomeres did not change during treatment, since it probably takes a longer time for such changes to take place. There was no change in telomere length, telomerase or glutathione peroxidise over the nine weeks before treatment commenced, which attests to the stability of the measurements. Control analyses also excluded such parameters as smoking, BMI and current medication as explanatory factors.


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REFERENCES:

Kristoffer N. T. Månsson et al. Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational Psychiatry, online 19 December 2019, https://www.nature.com/articles/s41398-019-0668-2