All of us at anxietycentre.com have experienced debilitating anxiety. But we’ve also overcome it and returned to normal and lasting health. Because we know the hardship anxiety unwellness can cause, we are committed to helping others, with over 27 years of service.” - Jim Folk, President, anxietycentre.com

The Chemical Imbalance Theory cause for anxiety disorder and depression officially laid to rest

The Chemical Imbalance theory has finally been officially debunked.

Over the last number of years, study after study challenged the validity of the chemical imbalance theory as being a cause of anxiety disorder and depression. Finally, on July 11, 2011, Dr. Ronald Pies, the editor-in-chief emeritus of the Psychiatric Times, laid the theory to rest in the July 11, 2011, issue of the Times with his admission:

“In the past 30 years, I don’t believe I have ever heard a knowledgeable, well- trained psychiatrist make such a preposterous claim [about chemical imbalance in the brain], except perhaps to mock it.”

“And yes, the ‘chemical imbalance’ image has been vigorously promoted by some pharmaceutical companies, often to the detriment of our patients’ understanding.”

“In truth, the “chemical imbalance” notion was always a kind of urban legend - never a theory seriously propounded by well-informed psychiatrists.”

Shortly after, pharmaceutical companies said they used the chemical imbalance theory as a “metaphor” and that the theory wasn’t ever intended to be understood as an actual imbalance. It wasn’t long after that that the chemical imbalance notion was dropped from all of their marketing materials.

Anxiety is NOT caused by a chemical imbalance in the brain. It never was.

For more detailed information about the demise of the Chemical Imbalance theory.

The combination of good self-help information and working with an experienced anxiety disorder therapist, coach, or counselor is the most effective way to address anxiety and its many symptoms. Until the core causes of anxiety are addressed - we call these core causes the underlying factors of anxiety - a struggle with anxiety unwellness can return again and again. Dealing with the underlying factors of anxiety is the best way to address problematic anxiety.


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Authors: Jim Folk, Marilyn Folk, BScN. Last updated July 2016.

anxietycentre.com: Information, support, and coaching/counseling/therapy for problematic anxiety and its sensations and symptoms, including the anxiety news item: The Chemical Imbalance theory officially laid to rest.