SSRIs associated with 40% increase in bleeding risk when used with aspirin
A recent study has found that "patients taking both aspirin and an SSRI had a 42% increased risk of a bleeding episode - gastrointestinal bleeding, hemorrhagic stroke or other bleeding that required hospital admission - compared with those taking aspirin alone."
"Study lead Dr Elham Rahme, assistant professor at McGill University, Montreal, Canada said: 'Clinicians must weigh the benefits of SSRI therapy against the risk of bleeding in patients with major depression following acute myocardial infarction.'"
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Authors: Jim Folk, Marilyn Folk, BScN. Last updated July 2016.